Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1

The mitotic spindle checkpoint protein Bub1 has been found to be mutated at low frequency in certain human cancers characterized by aneuploidy. Simian virus 40 large T antigen efficiently immortalizes rodent cells and occasionally transforms them to tumorigenicity. T antigen can also cause genomic i...

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Main Authors: Cotsiki, Marina, Lock, Rowena L., Cheng, Yuan, Williams, Grace L., Zhao, Jean, Perera, David, Freire, Raimundo, Entwistle, Alan, Golemis, Erica A., Roberts, Thomas M., Jat, Parmjit S., Gjoerup, Ole V.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC327122/
https://ncbi.nlm.nih.gov/pubmed/14732683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308006100
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