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Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity
The prototypical fibroblast growth factor receptor (FGFR) extracellular domain consists of three Ig domains (D1–D3) of which the two membrane-proximal D2 and D3 domains and the interconnecting D2–D3 linker bear the determinants of ligand binding and specificity. In contrast, D1 and the D1–D2 linker...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC327120/ https://ncbi.nlm.nih.gov/pubmed/14732692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307287101 |
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