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Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity

The prototypical fibroblast growth factor receptor (FGFR) extracellular domain consists of three Ig domains (D1–D3) of which the two membrane-proximal D2 and D3 domains and the interconnecting D2–D3 linker bear the determinants of ligand binding and specificity. In contrast, D1 and the D1–D2 linker...

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Wedi'i Gadw mewn:
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Olsen, Shaun K., Ibrahimi, Omar A., Raucci, Angela, Zhang, Fuming, Eliseenkova, Anna V., Yayon, Avner, Basilico, Claudio, Linhardt, Robert J., Schlessinger, Joseph, Mohammadi, Moosa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2004
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327120/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14732692/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307287101
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