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The Development of the Enantioselective Addition of Ethyl Diazoacetate to Aldehydes: Asymmetric Synthesis of 1,2-Diols

A novel synthetic strategy towards the asymmetric synthesis of vicinal diols bearing a tertiary center is presented. The method encompasses the dinuclear Mg-catalyzed asymmetric addition of ethyl diazoacetate into several aldehydes, oxidation of the diazo functionality, and diastereoselective alkyl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Trost, Barry M., Malhotra, Sushant, Koschker, Philipp, Ellerbrock, Pascal
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271135/
https://ncbi.nlm.nih.gov/pubmed/22088096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja206995s
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