Quinoline Derivatives Are Therapeutic Candidates for Transmissible Spongiform Encephalopathies

We previously reported that quinacrine inhibited the formation of an abnormal prion protein (PrPres), a key molecule in the pathogenesis of transmissible spongiform encephalopathy, or prion disease, in scrapie-infected neuroblastoma cells. To elucidate the structural aspects of its inhibiting action...

Full description

Bibliographic Details

Published in:	J Virol
Main Authors:	Murakami-Kubo, Ikuko, Doh-ura, Katsumi, Ishikawa, Kensuke, Kawatake, Satoshi, Sasaki, Kensuke, Kira, Jun-ichi, Ohta, Shigeru, Iwaki, Toru
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2004
Subjects:	Vaccines and Antiviral Agents
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327112/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14722283/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.3.1281-1288.2004
Tags:	Add Tag No Tags, Be the first to tag this record!