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Quinoline Derivatives Are Therapeutic Candidates for Transmissible Spongiform Encephalopathies

We previously reported that quinacrine inhibited the formation of an abnormal prion protein (PrPres), a key molecule in the pathogenesis of transmissible spongiform encephalopathy, or prion disease, in scrapie-infected neuroblastoma cells. To elucidate the structural aspects of its inhibiting action...

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Udgivet i:J Virol
Principais autores: Murakami-Kubo, Ikuko, Doh-ura, Katsumi, Ishikawa, Kensuke, Kawatake, Satoshi, Sasaki, Kensuke, Kira, Jun-ichi, Ohta, Shigeru, Iwaki, Toru
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327112/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14722283/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.3.1281-1288.2004
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