Gu-4 Suppresses Affinity and Avidity Modulation of CD11b and Improves the Outcome of Mice with Endotoxemia and Sepsis

BACKGROUND: Systemic leukocyte activation and disseminated leukocyte adhesion will impair the microcirculation and cause severe decrements in tissue perfusion and organ function in the process of severe sepsis. Gu-4, a lactosyl derivative, could selectively target CD11b to exert therapeutic effect i...

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Главные авторы: Yan, TingTing, Li, Qing, Zhou, HuiTing, Zhao, YueTao, Yu, ShuQin, Xu, GuangLin, Yin, ZhiMin, Li, ZhongJun, Zhao, ZhiHui
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271073/
https://ncbi.nlm.nih.gov/pubmed/22319560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030110
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