A Dual-Role of Gu-4 in Suppressing HMGB1 Secretion and Blocking HMGB1 Pro-Inflammatory Activity during Inflammation

BACKGROUND: High mobility group box 1(HMGB1) was first recognized as a nuclear protein that increased the chromatin remodeling and regulates transcription of many genes. In recent years, HMGB1 has been identified as a critical “late” pro-inflammatory mediator due to its unique secretion pattern and...

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Main Authors: Zhou, HuiTing, Ji, XueMei, Wu, Yun, Xuan, Ju, Qi, ZhiLin, Shen, Lei, Lan, Lei, Li, Qing, Yin, ZhiMin, Li, ZhongJun, Zhao, ZhiHui
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945943/
https://ncbi.nlm.nih.gov/pubmed/24603876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089634
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