Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons

BACKGROUND: Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson's disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic neurons, more extensive yet regionally selective neurodegeneration is obse...

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Autori principali: Cabeza-Arvelaiz, Yofre, Fleming, Sheila M, Richter, Franziska, Masliah, Eliezer, Chesselet, Marie-Francoise, Schiestl, Robert H
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271045/
https://ncbi.nlm.nih.gov/pubmed/22165993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-83
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