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Epidermal Growth Factor Receptor (EGFR)-mediated Positive Feedback of Protein-tyrosine Phosphatase ϵ (PTPϵ) on ERK1/2 and AKT Protein Pathways Is Required for Survival of Human Breast Cancer Cells

Increased tyrosine phosphorylation has been correlated with human cancer, including breast cancer. In general, the activation of tyrosine kinases (TKs) can be antagonized by the action of protein-tyrosine phosphatases (PTPs). However, in some cases PTPs can potentiate the activation of TKs. In this...

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書目詳細資料
Main Authors: Nunes-Xavier, Caroline E., Elson, Ari, Pulido, Rafael
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270997/
https://ncbi.nlm.nih.gov/pubmed/22117074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.293928
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