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Acyl Chain Specificity of Ceramide Synthases Is Determined within a Region of 150 Residues in the Tram-Lag-CLN8 (TLC) Domain

In mammals, ceramides are synthesized by a family of six ceramide synthases (CerS), transmembrane proteins located in the endoplasmic reticulum, where each use fatty acyl-CoAs of defined chain length for ceramide synthesis. Little is known about the molecular features of the CerS that determine acyl...

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Bibliografiset tiedot
Päätekijät: Tidhar, Rotem, Ben-Dor, Shifra, Wang, Elaine, Kelly, Samuel, Merrill, Alfred H., Futerman, Anthony H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270974/
https://ncbi.nlm.nih.gov/pubmed/22144673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.280271
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