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p21 Cooperates with DDB2 Protein in Suppression of Ultraviolet Ray-induced Skin Malignancies
Exposure to ultraviolet rays (UV) in sunlight is the main cause of skin cancer. Here, we show that the p53-induced genes DDB2 and p21 are down-regulated in skin cancer, and in the mouse model they functionally cooperate to prevent UV-induced skin cancer. Our previous studies demonstrated an antagoni...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3270959/ https://ncbi.nlm.nih.gov/pubmed/22167187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.295816 |
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