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Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations

The crystal structures of acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis (Mtb) and Corynebacterium ammoniagenes determined at pH 5.3 and pH 6.5, respectively, are reported. Comparison of the Mtb apo-AcpS structure with the recently reported structure of the Mtb AcpS–ADP complex...

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Main Authors: Gokulan, Kuppan, Aggarwal, Anup, Shipman, Lance, Besra, Gurdyal S., Sacchettini, James C.
格式: Artigo
語言:Inglês
出版: International Union of Crystallography 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270384/
https://ncbi.nlm.nih.gov/pubmed/21697604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911020221
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