Loss of TGF-β Signaling and PTEN Promotes Head and Neck Squamous Cell Carcinoma through Cellular Senescence Evasion and Cancer-related Inflammation

The molecular mechanisms that contribute to the initiation and progression of head and neck squamous cell carcinoma (HNSCC) have not been completely delineated. Our observations indicate that defects in the TGF-β and PI3K/Akt signaling pathways are common in human HNSCCs. Conditional activation of t...

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Detalhes bibliográficos
Main Authors: Bian, Yansong, Hall, Bradford, Sun, Zhi-Jun, Molinolo, Alfredo, Chen, Wanjun, Gutkind, J. Silvio, Van Waes, Carter, Kulkarni, Ashok B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270146/
https://ncbi.nlm.nih.gov/pubmed/22037217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.494
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