Progressive Tumor Formation in Mice with Conditional Deletion of TGF-β Signaling in Head and Neck Epithelia Is Associated with Activation of the PI3k/Akt Pathway

The precise role of TGF-β signaling in head and neck squamous cell carcinoma (HNSCC) is not yet fully understood. Here we report generation of an inducible head- and neck-specific knockout mouse model by crossing TGF-β receptor I (Tgfbr1) floxed mice with K14-CreER(tam) mice. By applying tamoxifen (...

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Detalhes bibliográficos
Main Authors: Bian, Yansong, Terse, Anita, Du, Juan, Hall, Bradford, Molinolo, Alfredo, Zhang, Pin, Chen, Wanjun, Flanders, Kathleen C., Gutkind, J. Silvio, Wakefield, Lalage M., Kulkarni, Ashok B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758611/
https://ncbi.nlm.nih.gov/pubmed/19584284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4623
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