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A New Reagent for Direct Difluoromethylation

Molecular scaffolds containing alkylfluorine substituents are desired in many areas of chemical research from materials to pharmaceuticals. Herein, we report the invention of a new reagent (Zn(SO(2)CF(2)H)(2), DFMS) for the innate difluoromethylation of organic substrates via a radical process. This...

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Main Authors: Fujiwara, Yuta, Dixon, Janice A., Rodriguez, Rodrigo A., Baxter, Ryan D., Dixon, Darryl D., Collins, Michael R., Blackmond, Donna G., Baran, Phil S.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269891/
https://ncbi.nlm.nih.gov/pubmed/22229949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja211422g
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