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Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record

BACKGROUND: Susceptibility variants identified by genome-wide association studies (GWAS) have modest effect sizes. Whether such variants provide incremental information in assessing risk for common 'complex' diseases is unclear. We investigated whether measured and imputed genotypes from a...

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Главные авторы: Ding, Keyue, Bailey, Kent R, Kullo, Iftikhar J
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269823/
https://ncbi.nlm.nih.gov/pubmed/22151179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2261-11-66
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