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Reactive Nitrogen Species in Acetaminophen-Induced Mitochondrial Damage and Toxicity in Mouse Hepatocytes
Acetaminophen (APAP) toxicity in primary mouse hepatocytes occurs in two phases. The initial phase (0–2 h) occurs with metabolism to N-acetyl-p-benzoquinoneimine which depletes glutathione, and covalently binds to proteins, but little toxicity is observed. Subsequent washing of hepatocytes to remove...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3269780/ https://ncbi.nlm.nih.gov/pubmed/20578685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx1001755 |
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