Inhibition of AKT2 Enhances Sensitivity to Gemcitabine via Regulating PUMA and NF-κB Signaling Pathway in Human Pancreatic Ductal Adenocarcinoma

Invasion, metastasis and resistance to conventional chemotherapeutic agents are obstacles to successful treatment of pancreatic cancer, and a better understanding of the molecular basis of this malignancy may lead to improved therapeutics. In the present study, we investigated whether AKT2 silencing...

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Autores principales: Chen, Dong, Niu, Min, Jiao, Xuelong, Zhang, Kejun, Liang, Jun, Zhang, Dianliang
Formato: Artigo
Lenguaje:Inglês
Publicado: Molecular Diversity Preservation International (MDPI) 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269746/
https://ncbi.nlm.nih.gov/pubmed/22312312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms13011186
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