Efficient Uptake of Recombinant α-Galactosidase A Produced with a Gene-Manipulated Yeast by Fabry Mice Kidneys

To economically produce recombinant human α-galactosidase A (GLA) with a cell culture system that does not require bovine serum, we chose methylotrophic yeast cells with the OCH1 gene, which encodes α-1,6-mannosyltransferase, deleted and over-expressing the Mnn4p (MNN4) gene, which encodes a positiv...

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Autors principals: Tsukimura, Takahiro, Kawashima, Ikuo, Togawa, Tadayasu, Kodama, Takashi, Suzuki, Toshihiro, Watanabe, Toru, Chiba, Yasunori, Jigami, Yoshifumi, Fukushige, Tomoko, Kanekura, Takuro, Sakuraba, Hitoshi
Format: Artigo
Idioma:Inglês
Publicat: ScholarOne 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269645/
https://ncbi.nlm.nih.gov/pubmed/22033676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00248
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