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Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn(2+)/Mn(2+)) to monometallic (Zn(2+)-only) behavior
A deoxyribozyme that hydrolyzes DNA phosphodiester linkages with a requirement for both Zn(2+) and Mn(2+) is switched by only two nucleotide mutations to require Zn(2+) alone, demonstrating that DNA-catalyzed DNA hydrolysis can be achieved using only one metal ion cofactor.
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3269124/ https://ncbi.nlm.nih.gov/pubmed/21125108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cc04575f |
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