Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer

BACKGROUND & AIMS: The Toll-like receptor (TLR) 4 mediates homeostasis of the intestinal epithelial cell (IEC) barrier. We investigated the effects of TLR4-D299G on IEC functions. METHODS: We engineered IECs (Caco-2) to stably overexpress hemagglutinin-tagged wild-type TLR4, TLR4-D299G, or TLR4-...

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Main Authors: Eyking, Annette, Ey, Birgit, Rünzi, Michael, Roig, Andres I., Reis, Henning, Schmid, Kurt W., Gerken, Guido, Podolsky, Daniel K., Cario, Elke
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268964/
https://ncbi.nlm.nih.gov/pubmed/21920464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.08.043
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