Loss of TLR2 Worsens Spontaneous Colitis in MDR1A Deficiency through Commensally Induced Pyroptosis

Variants of the multidrug resistance gene (MDR1/ABCB1) have been associated with increased susceptibility to severe ulcerative colitis (UC). In this study, we investigated the role of TLR/IL-1R signaling pathways including the common adaptor MyD88 in the pathogenesis of chronic colonic inflammation...

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Detalhes bibliográficos
Main Authors: Ey, Birgit, Eyking, Annette, Klepak, Magdalena, Salzman, Nita H., Göthert, Joachim R., Rünzi, Michael, Schmid, Kurt W., Gerken, Guido, Podolsky, Daniel K., Cario, Elke
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2013
Assuntos:
Innate Immunity and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659955/
https://ncbi.nlm.nih.gov/pubmed/23636052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201592
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