Loss of TLR2 Worsens Spontaneous Colitis in MDR1A Deficiency through Commensally Induced Pyroptosis

Variants of the multidrug resistance gene (MDR1/ABCB1) have been associated with increased susceptibility to severe ulcerative colitis (UC). In this study, we investigated the role of TLR/IL-1R signaling pathways including the common adaptor MyD88 in the pathogenesis of chronic colonic inflammation...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Ey, Birgit, Eyking, Annette, Klepak, Magdalena, Salzman, Nita H., Göthert, Joachim R., Rünzi, Michael, Schmid, Kurt W., Gerken, Guido, Podolsky, Daniel K., Cario, Elke
Format: Artigo
Langue:Inglês
Publié: AAI 2013
Sujets:
Innate Immunity and Inflammation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659955/
https://ncbi.nlm.nih.gov/pubmed/23636052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201592
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires