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Structural requirements for efficient prion protein conversion: Cofactors may promote a conversion-competent structure for PrP(C)

To understand why cross-species infection of prion disease often results in inefficient transmission and reduced protein conversion, most research has focused on defining the effect of variations in PrP primary structures, including sequence compatibility of substrate and seed. By contrast, little r...

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Bibliografiske detaljer
Main Authors: Gill, Andrew C, Agarwal, Sonya, Pinheiro, Teresa JT, Graham, James F
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268955/
https://ncbi.nlm.nih.gov/pubmed/20864807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.4.4.13394
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