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Cocaine facilitates PKC maturation by upregulating its phosphorylation at the activation loop in rat striatal neurons in vivo

Newly synthesized protein kinase C (PKC) undergoes a series of phosphorylation to render a mature form of the enzyme. It is this mature PKC that possesses the catalytic competence to respond to second messengers for activation and downstream signaling. The first and rate-limiting phosphorylation occ...

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Detalhes bibliográficos
Main Authors: Xue, Bing, Guo, Ming-Lei, Jin, Dao-Zhong, Mao, Li-Min, Wang, John Q.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268888/
https://ncbi.nlm.nih.gov/pubmed/22208647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2011.11.024
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