Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons

Kv7 channels determine the resting membrane potential of neurons and regulate their excitability. Even though dysfunction of Kv7 channels has been linked to several debilitating childhood neuronal disorders, the ontogeny of the constituent genes, which encode Kv7 channels (KNCQ), and expression of t...

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Veröffentlicht in:Pflugers Arch
Hauptverfasser: Telezhkin, Vsevolod, Straccia, Marco, Yarova, Polina, Pardo, Monica, Yung, Sun, Vinh, Ngoc-Nga, Hancock, Jane M., Barriga, Gerardo Garcia-Diaz, Brown, David A., Rosser, Anne E., Brown, Jonathan T., Canals, Josep M., Randall, Andrew D., Allen, Nicholas D., Kemp, Paul J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2018
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096767/
https://ncbi.nlm.nih.gov/pubmed/29797067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-018-2155-7
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