Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus

OBJECTIVE: Several confirmed genetic susceptibility loci for lupus have been described. To date, no clear evidence for genetic epistasis is established in lupus. We test for gene-gene interactions in a number of known lupus susceptibility loci. METHODS: Eighteen SNPs tagging independent and confirme...

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Autori principali: Hughes, Travis, Adler, Adam, Kelly, Jennifer A., Kaufman, Kenneth M., Williams, Adrienne, Langefeld, Carl D., Brown, Elizabeth E., Alarcón, Graciela S., Kimberly, Robert P., Edberg, Jeffrey C., Ramsey-Goldman, Rosalind, Petri, Michelle, Boackle, Susan A., Stevens, Anne M., Reveille, John D., Sanchez, Elena, Martin, Javier, Niewold, Timothy B., Vilá, Luis M., Scofield, R Hal, Gilkeson, Gary S., Gaffney, Patrick M., Criswell, Lindsey A., Moser, Kathy L., Merrill, Joan T., Jacob, Chaim O., Tsao, Betty P., James, Judith A., Vyse, Timothy J., Alarcón-Riquelme, Marta E., Harley, John B., Richardson, Bruce C., Sawalha, Amr H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268866/
https://ncbi.nlm.nih.gov/pubmed/21952918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.33354
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