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Stereochemical and neuroanatomical selectivity of pramipexole effects on sensorimotor gating in rats

BACKGROUND: In rats, prepulse inhibition (PPI) of acoustic startle is disrupted by systemic administration of dopaminergic agonists, such as the dopamine D3 receptor (D3R)-preferential agonist pramipexole (PPX). PPX has D3R-active (S) and -inactive (R) stereoisomers. Here, we tested the neuroanatomi...

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Main Authors: Chang, Wei-li, Weber, Martin, Breier, Michelle R., Saint Marie, Richard L., Hines, Samantha R., Swerdlow, Neal R.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268831/
https://ncbi.nlm.nih.gov/pubmed/22227455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2011.12.007
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