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On using samples of known protein content to assess the statistical calibration of scores assigned to peptide-spectrum matches in shotgun proteomics

In shotgun proteomics, the quality of a hypothesized match between an observed spectrum and a peptide sequence is quantified by a score function. Because the score function lies at the heart of any peptide identification pipeline, this function greatly affects the final results of a proteomics assay...

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Detalhes bibliográficos
Main Authors: Granholm, Viktor, Noble, William Stafford, Käll, Lukas
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268674/
https://ncbi.nlm.nih.gov/pubmed/21391616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr1012619
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