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Exometabolome Analysis Identifies Pyruvate Dehydrogenase as a Target for the Antibiotic Triphenylbismuthdichloride in Multiresistant Bacterial Pathogens

The desperate need for new therapeutics against notoriously antibiotic-resistant bacteria has led to a quest for novel antibacterial target structures and compounds. Moreover, defining targets and modes of action of new antimicrobial compounds remains a major challenge with standard technologies. He...

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Detalhes bibliográficos
Main Authors: Birkenstock, Timo, Liebeke, Manuel, Winstel, Volker, Krismer, Bernhard, Gekeler, Cordula, Niemiec, Maria J., Bisswanger, Hans, Lalk, Michael, Peschel, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268445/
https://ncbi.nlm.nih.gov/pubmed/22144679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.288894
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