Pyruvate Formate Lyase Acts as a Formate Supplier for Metabolic Processes during Anaerobiosis in Staphylococcus aureus

Previous studies demonstrated an upregulation of pyruvate formate lyase (Pfl) and NAD-dependent formate dehydrogenase (Fdh) in Staphylococcus aureus biofilms. To investigate their physiological role, we constructed fdh and pfl deletion mutants (Δfdh and Δpfl). Although formate dehydrogenase activity...

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Bibliographic Details
Main Authors: Leibig, Martina, Liebeke, Manuel, Mader, Diana, Lalk, Michael, Peschel, Andreas, Götz, Friedrich
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2011
Subjects:
Physiology and Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028676/
https://ncbi.nlm.nih.gov/pubmed/21169491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01161-10
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