Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders

Nuclear factor κB (NF-κB) is a transcription factor that regulates various aspects of immune response, cell death, and differentiation as well as cancer. In this study we introduce the Py-Im polyamide 1 that binds preferentially to the sequences 5′-WGGWWW-3′ and 5′GGGWWW-3′. The compound is capable...

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Bibliographic Details
Main Authors: Raskatov, Jevgenij A., Meier, Jordan L., Puckett, James W., Yang, Fei, Ramakrishnan, Parameswaran, Dervan, Peter B.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268328/
https://ncbi.nlm.nih.gov/pubmed/22203967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118506109
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