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Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders
Nuclear factor κB (NF-κB) is a transcription factor that regulates various aspects of immune response, cell death, and differentiation as well as cancer. In this study we introduce the Py-Im polyamide 1 that binds preferentially to the sequences 5′-WGGWWW-3′ and 5′GGGWWW-3′. The compound is capable...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3268328/ https://ncbi.nlm.nih.gov/pubmed/22203967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118506109 |
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