Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1

BACKGROUND: Bcl-2 is believed to contribute to melanoma chemoresistance. However, expression of Bcl-2 proteins may be different among melanomas. Thus correlations among expression of Bcl-2-related proteins and in vivo melanoma progression, and resistance to combination therapies, was investigated. M...

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Hauptverfasser: Mena, Salvador, Rodriguez, María L, Ortega, Angel, Priego, Sonia, Obrador, Elena, Asensi, Miguel, Petschen, Ignacio, Cerdá, Miguel, Brown, Bob D, Estrela, José M
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268086/
https://ncbi.nlm.nih.gov/pubmed/22233801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-8
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