Decreased collagen-induced arthritis severity and adaptive immunity in mitogen activated protein kinase kinase 6 -deficient mice

OBJECTIVE: MAPK kinases MKK3 and MKK6 regulate p38 MAPK activation in inflammatory diseases such as rheumatoid arthritis. Previous studies demonstrated that MKK3- or MKK6-deficiency inhibits K/BxN serum-induced arthritis. However, the role of these kinases in adaptive immunity-dependent models of ch...

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Detalhes bibliográficos
Main Authors: Hammaker, Deepa, Topolewski, Katharyn, Edgar, Meghan, Yoshizawa, Toshio, Fukushima, Akihisa, Boyle, David L., Firestein, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267851/
https://ncbi.nlm.nih.gov/pubmed/21953132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.33359
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