Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1

Ribonucleotide reductase (RNR) activity requires an electron donor, which in bacteria, yeast, and plants is usually either reduced thioredoxin (Trx) or reduced glutaredoxin (Grx). Mice lacking glutathione reductase are viable and, although mice lacking thioredoxin reductase 1 (TrxR1) are embryonic-l...

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Autors principals: Prigge, Justin R., Eriksson, Sofi, Iverson, Sonya V., Meade, Tesia A., Capecchi, Mario R., Arnér, Elias S.J., Schmidt, Edward E.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267845/
https://ncbi.nlm.nih.gov/pubmed/22198266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.11.025
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