A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification

Besides helping to maintain a reducing intracellular environment, the thioredoxin (Trx) system impacts bioenergetics and drug-metabolism. We show that hepatocyte-specific disruption of Txnrd1, encoding Trx reductase-1 (TrxR1), causes a metabolic switch in which lipogenic genes are repressed and peri...

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Hlavní autoři: Iverson, Sonya V., Eriksson, Sofi, Xu, Jianqiang, Prigge, Justin R., Talago, Emily A., Meade, Tesia A., Meade, Erin S., Capecchi, Mario R., Arnér, Elias S.J., Schmidt, Edward E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827783/
https://ncbi.nlm.nih.gov/pubmed/23743293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.05.028
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