The PI3-Kinase/mTOR-Targeting Drug NVP-BEZ235 Inhibits Growth and IgE-Dependent Activation of Human Mast Cells and Basophils

The phosphoinositide 3-kinase (PI3-kinase) and the mammalian target of rapamycin (mTOR) are two major signaling molecules involved in growth and activation of mast cells (MC) and basophils (BA). We examined the effects of the dual PI3-kinase/mTOR blocker NVP-BEZ235 on growth of normal and neoplastic...

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Detalhes bibliográficos
Main Authors: Blatt, Katharina, Herrmann, Harald, Mirkina, Irina, Hadzijusufovic, Emir, Peter, Barbara, Strommer, Sabine, Hoermann, Gregor, Mayerhofer, Matthias, Hoetzenecker, Konrad, Klepetko, Walter, Ghanim, Viviane, Marth, Katharina, Füreder, Thorsten, Wacheck, Volker, Valenta, Rudolf, Valent, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267720/
https://ncbi.nlm.nih.gov/pubmed/22299028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029925
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