Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity

BACKGROUND: Proteolytic enzymes have been implicated in driving tumor progression by means of their cancer cell microenvironment activity where they promote proliferation, differentiation, apoptosis, migration, and invasion. Therapeutic strategies have focused on attenuating their activity using sma...

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Autores principales: Kwok, Hang Fai, Buick, Richard J, Kuehn, Diana, Gormley, Julie A, Doherty, Declan, Jaquin, Thomas J, McClurg, Angela, Ward, Claire, Byrne, Teresa, Jaworski, Jacob, Leung, Ka Lai, Snoddy, Philip, McAnally, Christine, Burden, Roberta E, Gray, Breena, Lowry, Jenny, Sermadiras, Isabelle, Gruszka, Natalia, Courtenay-Luck, Nigel, Kissenpfennig, Adrien, Scott, Christopher J, Johnston, James A, Olwill, Shane A
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267679/
https://ncbi.nlm.nih.gov/pubmed/22168338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-147
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