Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF

BACKGROUND: Angiogenesis is a key hallmark of tumourigenesis and its inhibition is a proven strategy for the development of novel anti-cancer therapeutics. An important aspect of early angiogenesis is the co-ordinated migration and invasion of endothelial cells through the hypoxic tumour tissue. Cat...

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Main Authors: Ward, Claire, Kuehn, Diana, Burden, Roberta E., Gormley, Julie A., Jaquin, Thomas J., Gazdoiu, Mihaela, Small, Donna, Bicknell, Roy, Johnston, James A., Scott, Christopher J., Olwill, Shane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932732/
https://ncbi.nlm.nih.gov/pubmed/20824056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012543
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