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Thermodynamics of Ligand Binding to a Heterogeneous RNA Population in the Malachite Green Aptamer

The malachite green aptamer binds two closely related ligands, malachite green (MG) and tetramethylrosamine (TMR), with near equal affinity. The MG ligand consists of three phenyl rings emanating from a central carbon, while TMR has two of the three rings connected by an ether linkage. The binding p...

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Main Authors: Sokoloski, Joshua E., Dombrowski, Sarah E., Bevilacqua, Philip C.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267630/
https://ncbi.nlm.nih.gov/pubmed/22192051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201642p
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