Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

The maintenance of genomic stability relies on the spindle assembly checkpoint (SAC), which ensures accurate chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bioriented and attached to the mitotic spindle. BUB1 and BUBR1 kinases are central for this process...

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Main Authors: Bolanos-Garcia, Victor M., Lischetti, Tiziana, Matak-Vinković, Dijana, Cota, Ernesto, Simpson, Pete J., Chirgadze, Dimitri Y., Spring, David R., Robinson, Carol V., Nilsson, Jakob, Blundell, Tom L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267040/
https://ncbi.nlm.nih.gov/pubmed/22000412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.09.017
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