Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease

The morphology of healthy podocyte foot processes is necessary for maintaining the characteristics of the kidney filtration barrier. In most forms of glomerular disease, abnormal filter barrier function results when podocytes undergo foot process spreading and retraction by remodeling their cytoskel...

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Main Authors: George, Britta, Verma, Rakesh, Soofi, Abdulsalam A., Garg, Puneet, Zhang, Jidong, Park, Tae-Ju, Giardino, Laura, Ryzhova, Larisa, Johnstone, Duncan B., Wong, Hetty, Nihalani, Deepak, Salant, David J., Hanks, Steven K., Curran, Tom, Rastaldi, Maria Pia, Holzman, Lawrence B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266791/
https://ncbi.nlm.nih.gov/pubmed/22251701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60070
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