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Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis
Activation of the slit diaphragm protein Nephrin induces actin cytoskeletal remodeling resulting in lamellipodia formation in podocytes in vitro in a phosphatidylinositol-3 kinase, focal adhesion kinase, Cas, and Crk1/2-dependent fashion. In mice, podocyte-specific deletion of Crk1/2 prevents or att...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040156/ https://ncbi.nlm.nih.gov/pubmed/24499776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2013.556 |
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