IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

HBV infection remains a leading cause of death worldwide. IFN-α inhibits viral replication in vitro and in vivo, and pegylated IFN-α is a commonly administered treatment for individuals infected with HBV. The HBV genome contains a typical IFN-stimulated response element (ISRE), but the molecular mec...

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Autori principali: Belloni, Laura, Allweiss, Lena, Guerrieri, Francesca, Pediconi, Natalia, Volz, Tassilo, Pollicino, Teresa, Petersen, Joerg, Raimondo, Giovanni, Dandri, Maura, Levrero, Massimo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266786/
https://ncbi.nlm.nih.gov/pubmed/22251702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58847
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