Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B(12 )and folic acid on fracture incidence

BACKGROUND: Osteoporosis is a major health problem, and the economic burden is expected to rise due to an increase in life expectancy throughout the world. Current observational evidence suggests that an elevated homocysteine concentration and poor vitamin B(12 )and folate status are associated with...

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Détails bibliographiques
Auteurs principaux: van Wijngaarden, Janneke P, Dhonukshe-Rutten, Rosalie AM, van Schoor, Natasja M, van der Velde, Nathalie, Swart, Karin MA, Enneman, Anke W, van Dijk, Suzanne C, Brouwer-Brolsma, Elske M, Zillikens, M Carola, van Meurs, Joyce BJ, Brug, Johannes, Uitterlinden, André G, Lips, Paul, de Groot, Lisette CPGM
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2011
Sujets:
Study Protocol
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266639/
https://ncbi.nlm.nih.gov/pubmed/22136481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2318-11-80
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