Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B(12 )and folic acid on fracture incidence

BACKGROUND: Osteoporosis is a major health problem, and the economic burden is expected to rise due to an increase in life expectancy throughout the world. Current observational evidence suggests that an elevated homocysteine concentration and poor vitamin B(12 )and folate status are associated with...

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Autori principali: van Wijngaarden, Janneke P, Dhonukshe-Rutten, Rosalie AM, van Schoor, Natasja M, van der Velde, Nathalie, Swart, Karin MA, Enneman, Anke W, van Dijk, Suzanne C, Brouwer-Brolsma, Elske M, Zillikens, M Carola, van Meurs, Joyce BJ, Brug, Johannes, Uitterlinden, André G, Lips, Paul, de Groot, Lisette CPGM
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Study Protocol
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266639/
https://ncbi.nlm.nih.gov/pubmed/22136481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2318-11-80
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