INCREASED ANGIOTENSIN II INDUCED HYPERTENSION AND INFLAMMATORY CYTOKINES IN MICE LACKING ANGIOTENSIN CONVERTING ENZYME N DOMAIN ACTIVITY

Angiotensin converting enzyme (ACE) is composed of the N- and C-terminal catalytic domains. To study the role of the ACE domains in the inflammatory response, N-KO and C-KO mice, models lacking one of the two ACE domains, were analyzed during angiotensin II-induced hypertension. At 2 weeks, N-KO mic...

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Detalhes bibliográficos
Main Authors: Ong, Frank S., Lin, Chentao X., Campbell, Duncan J., Okwan-Duodu, Derick, Chen, Xu, Blackwell, Wendell-Lamar B., Shah, Kandarp H., Gonzalez-Villalobos, Romer A., Shen, Xiao Z., Fuchs, Sebastien, Bernstein, Kenneth E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266456/
https://ncbi.nlm.nih.gov/pubmed/22203735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.111.180844
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