Regulated and Reversible Induction of Adult Human β-Cell Replication

Induction of proliferation in adult human β-cells is challenging. It can be accomplished by introduction of cell cycle molecules such as cyclin-dependent kinase 6 (cdk6) and cyclin D(1), but their continuous overexpression raises oncogenic concerns. We attempted to mimic normal, transient, perinatal...

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Hlavní autoři: Takane, Karen K., Kleinberger, Jeffery W., Salim, Fatimah G., Fiaschi-Taesch, Nathalie M., Stewart, Andrew F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2012
Témata:
Islet Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266420/
https://ncbi.nlm.nih.gov/pubmed/22210317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0580
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