Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity

Null mutations in the PCSK1 gene, encoding the proprotein convertase 1/3 (PC1/3), cause recessive monogenic early onset obesity. Frequent coding variants that modestly impair PC1/3 function mildly increase the risk for common obesity. The aim of this study was to determine the contribution of rare f...

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Autors principals: Creemers, John W.M., Choquet, Hélène, Stijnen, Pieter, Vatin, Vincent, Pigeyre, Marie, Beckers, Sigri, Meulemans, Sandra, Than, Manuel E., Yengo, Loïc, Tauber, Maithé, Balkau, Beverley, Elliott, Paul, Jarvelin, Marjo-Riitta, Van Hul, Wim, Van Gaal, Luc, Horber, Fritz, Pattou, François, Froguel, Philippe, Meyre, David
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2012
Matèries:
Obesity Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266396/
https://ncbi.nlm.nih.gov/pubmed/22210313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0305
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